This Desk Case is an object belonging to the Equipment faction. It has Archvillain class hit points and no ranged nor melee attacks, nor it can move.
Villains can find it on the Bust up the safehouse mission from Vince Dubrowski. (Levels 20-24)
It must be saved if you want to obtain a Clue. Saving the desk is NOT required to complete the mission successfully. Indeed, the mission can be finished even before engaging the Scrapyarders guarding the desk.
Initially the desk will have a group of Scrapyarders near who will start attacking it as soon as you aggro them. Even worse, at the very moment you aggro those, a wave of Scrapyarders will come and attack the item as well, so be ready to fight two groups at the same time before engaging. Once the first wave has been dealt with, a second will come. Once that has been defeated, a third (and last).
The contents of this desk are valuable.